Vulnerability to drug addiction in adolescents (ADOLs) may lead to faster rates of addiction and higher rates of relapse. The brain is developing in adolescence, including the prefrontal cortex (PFC) and the nucleus accumbens (NAc), which are regions involved in self-control and reward systems, respectively. Further, females, both human and rat models, often exhibit faster rates of addiction than males. Research from this lab has found previously that adult rats of both sexes exposed to amphetamine during ADOL had reduced expression of dopamine D1 receptors (D1R) in the medial PFC but no change in the NAc. The purpose of this current study is to determine how age and sex influence methamphetamine’s (METH) effects on the brain and behavior
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Alvarez, Jessica; Westbrook, Sarah; and Gulley, Joshua, "Methamphetamine Effects on Adolescent Brain Development in Both Sexes" (2018). PRECS 2018. 1.