Publication Date
Fall 2025
Abstract
Key Study
In "DNA Sequence Context Modulates the Impact of a Cisplatin 1,2-GpG Intrastrand Cross-Link", Pilch, Todd, and Lippard found that the DNA sequence around the binding site influences how tightly cisplatin binds (Pilch, Todd, and Lippard).
Biophysical techniques like melting temperature and circular dichroism showed that some sequences stabilize DNA more strongly after drug binding (Pilch, Todd, and Lippard).
This explains why cisplatin is more effective in some tumor genomes (Todd and Lippard).
Course
CHE 141: General Chemistry I
Rights
Copyright is owned by the creator of this work.
Recommended Citation
Elrouby, Radwa, "Stephen J. Lippard: Chemistry Meets Medicine" (2025). Natural Sciences Student Research Presentations. 187.
https://spark.parkland.edu/nsps/187
