Anhedonia is defined as a reduced or complete loss of pleasure from a previously pleasurable stimulus, and it is comprised of two dimensions:
- Hedonic anhedonia consists of a distinct loss of pleasure in consumption of a normally pleasurable stimulus.
- Motivational anhedonia involves the goal directed behavior to obtain a reward.
Withdrawal induced anhedonia following use of methamphetamine (METH) is thought to contribute to relapse behaviors1,2 . The anhedonic effects of drug withdrawal largely depend on dose, frequency, and the duration of drug exposure4,5,6.
The role of sex and age of exposure in this context has yet to be elucidated.
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Lewis, Cameron; Strumberger, Conor; and Gulley, Joshua M., "Role of Age and Sex in the Effects of Repeated Methamphetamine Exposure on Hedonic Tone in Sprague Dawley Rats" (2023). PRECS student projects. 104.