Characterizing the Regulatory Interaction Between FliZ and HilD in Salmonella

Authors

Kennedy K. Harris, Mott Community College
Gracious Donkor, University of Illinois at Urbana-Champaign
Matthew Georgiou, University of Illinois at Urbana-Champaign
James Slauch, University of Illinois at Urbana-Champaign

Document Type

Poster

Publication Date

2025

Abstract

• Salmonella Typhimurium utilizes a Type Three Secretion System (T3SS) encoded on Salmonella Pathogenicity Island 1 (SPI1) to invade host intestinal cells.
• The T3SS is a needle-like structure that penetrates intestinal cells and injects effector proteins into the cell's cytoplasm to induce uptake of Salmonella.
• Expression of the T3SS is controlled by HilA, which is in turn regulated by three transcriptional regulators: HilD, RtsA, and HilC (Fig. 1B). HilD is the main regulator of HilA.
• FliZ is a regulator of flagellar genes which also post-translationally controls the protein activity of HilD. FliZ induction increases activation of the hilA promoter.

Rights

Copyright is owned by the creators of this work.

Recommended Citation

Harris, Kennedy K.; Donkor, Gracious; Georgiou, Matthew; and Slauch, James, "Characterizing the Regulatory Interaction Between FliZ and HilD in Salmonella" (2025). MICRO-CCS student projects. 17.
https://spark.parkland.edu/micro_ccs_student/17