MICRO-CCS student projects

Document Type

Poster

Publication Date

2024

Abstract

Background

  • The increased virulence of Salmonella enterica in extraintestinal infections has been attributed to its ability survive and replicate in macrophage phagosome.
  • Salmonella can adapt to low pH and low Mg2+ conditions encountered in the phagosome. 1
  • To counteract the low magnesium conditions in the macrophage phagosome and ensure viability, intracellular polyamine (PA) production is critical. 1
  • Salmonella can synthesize putrescine in addition to other polyamines.

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